https://fernandobeserra.journoportfolio.comRSS Feed for Fernando Beserra, BPharm, MSc, Ph.D.enTue, 07 Jul 2026 00:00:00 +0100https://media.journoportfolio.com/users/512434/uploads/7409a0ad-68fe-4502-8d0e-a6708caecac2.pdfTue, 07 Jul 2026 00:00:00 +0100https://media.journoportfolio.com/users/512434/uploads/7409a0ad-68fe-4502-8d0e-a6708caecac2.pdfhttps://www.sciencedirect.com/science/chapter/bookseries/pii/B9780444636034000061The double bonds in the intact C-2 and C-3 and C-ring appear to be required for the strong activity [180]. Replacing the aromatic B ring with eitheralkyl group or heterocyclic ring or indole does not alter the gastroprotective properties [30]. Flavonoids, which have strong antioxidant activity, are believed to be beneficial for treating diabetes [100]. The double bonds in the intact C-2 and C-3 and C-ring appear to be required for the strong activity [180]. Replacing the aromatic B ring with ei...Tue, 07 Jul 2026 00:00:00 +0100https://www.sciencedirect.com/science/chapter/bookseries/pii/B9780444636034000061https://media.journoportfolio.com/users/512434/uploads/2c0f5f3c-dc09-40f6-b81e-1db0cc1eb432.pdfTue, 07 Jul 2026 00:00:00 +0100https://media.journoportfolio.com/users/512434/uploads/2c0f5f3c-dc09-40f6-b81e-1db0cc1eb432.pdfhttps://novapublishers.com/shop/epicatechin-sources-effects-and-research/Table of Contents Preface Chapter 1. Epicatechin: Sources and Health Benefits Ana C. Gonçalves, Catarina Bento, Fábio Jesus, Manuel Simões, Filipe Mergulhão, and Luís R. Silva (CICS – UBI – Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal, and others) Chapter 2. Preventive Properties of Green Tea Catechins against Metabolic Syndrome Kazuo Yamagata (Department of Food Science & Biotechnology, Nihon University, Fujisawa, Japan) Chapter 3. Epicatechin, a True Scienti...Tue, 07 Jul 2026 00:00:00 +0100https://novapublishers.com/shop/epicatechin-sources-effects-and-research/https://link.springer.com/article/10.1007/s00210-013-0947-zCardozo MT, de Conti A, Ong TP, Scolastici C, Purgatto E, Horst MA, Bassoli BK, Moreno FS (2011) Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem 22:130–135 Article  PubMed  CAS  Google Scholar Ji CX, Fan DS, Li W, Guo L, Xu ZL, Liang RM, Zhang JJ (2012) Evaluation of the anti-ulcerogenic activity of the antidepressants duloxe...Tue, 07 Jul 2026 00:00:00 +0100https://link.springer.com/article/10.1007/s00210-013-0947-zhttps://www.scielo.br/j/rbpm/a/Y5gdnf3KkGRdTX6GpbND7Nk/abstract/?lang=ptEste estudo objetivou caracterizar qualitativamente grupos de metabólitos secundários e alguns constituintes de 9 espécies de plantas medicinais nativas do cerrado utilizadas pela comunidade rural do Assentamento Vale Verde, identificando potencialidades biológicas e farmacológicas. As informações referentes às plantas de uso medicinal foram obtidas por meio de estudos etnobotânicos e etnofarmacológicos, realizados no período de 2010 a 2012. O material botânico coletado foi identificado e deposi...Tue, 07 Jul 2026 00:00:00 +0100https://www.scielo.br/j/rbpm/a/Y5gdnf3KkGRdTX6GpbND7Nk/abstract/?lang=pthttps://media.journoportfolio.com/users/512434/uploads/280b03a3-ffd3-4e84-90f2-a1f828c3dc80.pdfTue, 07 Jul 2026 00:00:00 +0100https://media.journoportfolio.com/users/512434/uploads/280b03a3-ffd3-4e84-90f2-a1f828c3dc80.pdfhttps://www.sciencedirect.com/science/article/pii/S0378874115004341?via%3DihubAll content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevan...Tue, 07 Jul 2026 00:00:00 +0100https://www.sciencedirect.com/science/article/pii/S0378874115004341?via%3Dihubhttps://pmc.ncbi.nlm.nih.gov/articles/PMC4783883/Cissus sicyoides Linneu (Vitaceae) originates from the Dominican Republic but its medicinal use is widespread in tropical America [1]. This medicinal plant known in Brazil as “Cortina”, “cipó-pucá”, “cortina japonesa”, “uva brava” and “insulina vegetal” is generally used in Brazilian folk medicine to treat: epilepsy, stroke, diabetes, gastric ulcer, abscesses, inflammation and rheumatoid arthritis [2,3,4]. In Mexico, this species known as “sanalotodo” is used in traditional medicine for relievin...Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC4783883/https://pubmed.ncbi.nlm.nih.gov/28012277/Diabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in...Tue, 07 Jul 2026 00:00:00 +0100https://pubmed.ncbi.nlm.nih.gov/28012277/https://pmc.ncbi.nlm.nih.gov/articles/PMC5592006/Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC5592006/https://www.jscimedcentral.com/jounal-article-pdf/JSM-Hepatitis/hepatitis-2-1008.pdfTue, 07 Jul 2026 00:00:00 +0100https://www.jscimedcentral.com/jounal-article-pdf/JSM-Hepatitis/hepatitis-2-1008.pdfhttps://www.jscimedcentral.com/jounal-article-info/JSM-Hepatitis/Evaluation-of-the-Gastroprotective-and-Antioxidant-Effects-of-Caffeine-and-Caffeic-Acid-on-EthanolInduced-Gastric-Ulcer--5857ABSTRACT Gastric ulcer (GU) is one of the most common disorders of the gastrointestinal tract. Among the nutritional aspects involved in GU trigger process we have the coffee intake. Caffeine (Caf) is one of the most known compounds of coffee, just as caffeic acid (CA) - a metabolic product from chlorogenic acids - and both have high antioxidant activity, which can protect the gastric mucosa, since oxidative stress can trigger the onset of GU. Because that, the aim of this study was to a...Tue, 07 Jul 2026 00:00:00 +0100https://www.jscimedcentral.com/jounal-article-info/JSM-Hepatitis/Evaluation-of-the-Gastroprotective-and-Antioxidant-Effects-of-Caffeine-and-Caffeic-Acid-on-EthanolInduced-Gastric-Ulcer--5857https://www.sciencedirect.com/science/article/pii/S0944711318303088?via%3DihubThus, it might be said that the gastroprotective effect of GA may be partly related to the stimulations of gastric nitric oxide and prostaglandin. A relationship between inflammation and the course of ethanol-induced gastric ulcer damage has been widely recognized [43,44]. Ethanol induces the inflammatory response that initiates macrophages produce vast amounts of pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α, which promote the accumulation of neutrophils in the inflammation site, lea...Tue, 07 Jul 2026 00:00:00 +0100https://www.sciencedirect.com/science/article/pii/S0944711318303088?via%3Dihubhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6278408/Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC6278408/https://www.sciencedirect.com/science/article/pii/S0009279717310487?via%3DihubStrictly Necessary CookiesAlways activeThese cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. Cookie Details List Strictly Necessary CookiesAlways active Always act...Tue, 07 Jul 2026 00:00:00 +0100https://www.sciencedirect.com/science/article/pii/S0009279717310487?via%3Dihubhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6532325/Diabetes mellitus (DM) is a chronic metabolic disease, which is characterized by elevated levels of blood glucose leading, over time, to heart, blood vessel, eye, kidney, and nerve damage and failure to repair damage in skin wounds [1]. According to the World Health Organization (WHO), this disease affects 171 million people worldwide, and this number may be projected to reach approximately 366 million by 2030 [2]. The most common complication in patients with diabetes is an altered skin wound h...Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC6532325/https://pubmed.ncbi.nlm.nih.gov/32935428/Propolis is a viscous resin consisting of plant material (shoots, flowers, and plant exudates), salivary secretions and waxes produced by Apis mellifera bees. Its popular use aroused the interests of scientific research, which proved to be a potential source of various bioactive substances. The chemical composition of propolis depends on several factors, such as the different types of plant sources collected by bees, geographic origin, and the time of year in which they are produced, but it is k...Tue, 07 Jul 2026 00:00:00 +0100https://pubmed.ncbi.nlm.nih.gov/32935428/https://www.mdpi.com/1422-0067/21/14/4952Tue, 07 Jul 2026 00:00:00 +0100https://www.mdpi.com/1422-0067/21/14/4952https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.763895/fullIntroductionMelanoma, although representing a minor fraction of all skin malignancies, remains the most lethal form (1, 2). Before the modern era, patients with advanced melanoma could expect a 5-year survival rate of 10% (3). Beginning in 2011, novel therapies, including immunotherapy with immune checkpoint inhibitors CTLA-4 or PD-1, as well as targeted therapy with BRAF and MEK inhibitors, have become a key breakthrough in the clinical landscape of melanoma treatment (4). Unprecedented in canc...Tue, 07 Jul 2026 00:00:00 +0100https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.763895/fullhttps://www.mdpi.com/1999-4923/13/11/1902Tue, 07 Jul 2026 00:00:00 +0100https://www.mdpi.com/1999-4923/13/11/1902https://pmc.ncbi.nlm.nih.gov/articles/PMC8307436/The skin is the largest organ of humans that acts as the first mechanical barrier between the organism and the external environmental, to protect organism against deleterious agents, control thermal regulation, and regulate water and electrolytes homeostasis [1]. The morphologic structure of skin comprises two layers, the epidermis and dermis [2]. The epidermis is the most external layer of the skin and is divided into four or five sub-layers, depending on the region of the body [2]. Among the c...Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC8307436/https://pdfs.semanticscholar.org/e409/7b4968858f6d356fd8d586f55ae837c9e348.pdfTue, 07 Jul 2026 00:00:00 +0100https://pdfs.semanticscholar.org/e409/7b4968858f6d356fd8d586f55ae837c9e348.pdfhttps://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.0R821Brazilian green propolis from Baccharis dracunculifolia (“alecrim do campo”), stands out for the majority presence of phenolic acids with therapeutic properties well-described in the literature, such as anti-inflammatory, antioxidant, and antitumor. However, its direct application, like many natural products, is limited due to its unfavorable physicochemical properties. Thus, we hypothesize that the encapsulation of these compounds in nanostructured systems is a suitable instrument to overcome t...Tue, 07 Jul 2026 00:00:00 +0100https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.0R821https://pmc.ncbi.nlm.nih.gov/articles/PMC9686645/Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC9686645/https://onlinelibrary.wiley.com/doi/10.1155/2022/9004014The skin is a critical organ for the maintenance of the integrity and protection of the organism. When a wound occurs, a sequence of healing mechanisms is triggered to reconstruct the wounded area. β-caryophyllene is a sesquiterpene in Copaifera langsdorffii oleoresin with antioxidant and anti-inflammatory potential. On the basis of previous studies with C. langsdorffii, β-caryophyllene was selected to evaluate its wound healing potential and pharmacological mechanisms. The excision wound model...Tue, 07 Jul 2026 00:00:00 +0100https://onlinelibrary.wiley.com/doi/10.1155/2022/9004014https://pmc.ncbi.nlm.nih.gov/articles/PMC10648863/The skin is essential to the integrity of the organism. The disruption of this organ promotes a wound, and the organism starts the healing to reconstruct the skin. Copaifera langsdorffii is a tree used in folk medicine to treat skin affections, with antioxidant and anti-inflammatory properties. In our study, the oleoresin of the plant was associated with nanostructured lipid carriers, aiming to evaluate the healing potential of this formulation and compare the treatment with reference drugs used...Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC10648863/https://www.sciencedirect.com/science/article/pii/S0009279722005221Strictly Necessary CookiesAlways activeThese cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. Cookie Details List Strictly Necessary CookiesAlways active Always act...Tue, 07 Jul 2026 00:00:00 +0100https://www.sciencedirect.com/science/article/pii/S0009279722005221https://www.sciencedirect.com/science/article/pii/S2666354624001728?__cf_chl_f_tk=wRay076bIxq05eIOsNlz606muMkuEThDa26bv7bcfvQ-1783450159-1.0.1.1-5NWGJdWEcjPE2Ybz1ZDMlBsoUxhr4vv3ULh1GzMK3qATue, 07 Jul 2026 00:00:00 +0100https://www.sciencedirect.com/science/article/pii/S2666354624001728?__cf_chl_f_tk=wRay076bIxq05eIOsNlz606muMkuEThDa26bv7bcfvQ-1783450159-1.0.1.1-5NWGJdWEcjPE2Ybz1ZDMlBsoUxhr4vv3ULh1GzMK3qAhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12845169/Tue, 07 Jul 2026 00:00:00 +0100https://pmc.ncbi.nlm.nih.gov/articles/PMC12845169/